RECENT PUBLICATIONS

  1. Keeping it together: structure, functions and applications of viral decoration proteins. Dedeo, C.L., Teschke, C.M.*, Alexandrescu, A.T.* (2020) Viruses. 12:1163. doi: 10.3390/v12101163. *co-corresponding authors (Review).

  2. NMR Mapping of Disordered Segments from a Viral Scaffolding Protein Encapsulated in a 23 MDa Procapsid Complex. Whitehead III, R.D., Teschke, C.M.*, Alexandrescu, A.T.* (2019) Biophys. J., 17(8):1387-1392. doi: 10.1016/j.bpj.2019.08.038. *co-corresponding authors

  3. Portal protein: the orchestrator of capsid assembly for the dsDNA tailed bacteriophages and herpesviruses. Dedeo C., Cingolani, G., Teschke, C.M. (2019) Ann. Review of Virology, 6:141-160. doi: 10.1146/annurev-virology-092818-015819

  4. Of capsid structure and stability: the partnership between charged residues of E-loop and P-domain of the bacteriophage P22 coat protein. Asija, K., Teschke C.M. (2019) Virology, 534:45-53. doi: 10.1016/j.virol.2019.05.021.

  5. A hydrophobic network: Intersubunit and intercapsomer interactions stabilizing the bacteriophage P22 capsid. Asija, K., Teschke, C.M. (2019) J. Virol., May 8. pii: JVI.00727-19. doi: 10.1128/JVI.00727-19.

  6. The phage L capsid decoration protein has a novel OB-fold and an unusual capsid binding strategy.  Newcomer, R.L., Schrad, J.R.,Gilcrease, E.B.,Casjens, S.R., Feig, M., Teschke, C.M., Alexandrescu, A.T., and Parent, K.N (2019) Elife, 8:e45345. doi: 10.7554/eLife.45345. 

  7. The amazing HK97 fold: versatile results of modest differences. Duda, R.L., Teschke, C.M. (2019) Curr. Opin. Virol., 36:9-16, doi: 10.1016/j.coviro.2019.02.001.

  8. The architect of virus assembly: portal protein nucleates procapsid assembly in bacteriophage P22. Motwani, T., Teschke, C.M. (2019). J. Virol., 93:e00187-19. doi: 0.1128/JVI.00187-19. Selected by editors for a JVi Spotlight.

  9. Conservation and divergence of the I-domain inserted into the ubiquitous HK97 coat protein fold in the P22-like bacteriophages. Tripler, T.N., Kaplan, A.R., Alexandrescu, A.T., and Teschke, C.M. (2019) J. Virol., 93:e00007-19. doi:10.1128/JVI.00007-19.

  10. NMR assignments of Decorator, a phage-cementing 43 kDa homotrimer. Newcomer, R.L., Belato, H., Teschke, C.M., Alexandrescu, A.A. (2018) Biomol. NMR Assignments. 12, 339-343. doi: 10.1007/s12104-018-9836-1 *co-corresponding authors

  11. Lessons from bacteriophages I: Deriving utility from protein structure, function and evolution. Asija, K., Teschke, C.M. (2018) PLOS Pathogens Pearls, 14, e1006971. doi:  10.137/journal.ppat.116971. .

  12. Lessons from bacteriophages II: A saga of scientific breakthroughs and prospects for their use in human health. Asija, K., Teschke, C.M. (2018) PLOS Pathogens Pearls, 14, e1006970. doi: 10.137/journal.ppat.116970.

  13. A viral scaffolding protein triggers portal ring oligomerization and incorporation during procapsid assembly. Motwani, T. Lokareddy, R.K., Dunbar, C.A., Cortines, J.R., Jarrold, M.F., Cingolani, G., Teschke, C.M. (2017) Sci. Advances, 3, e1700423. doi: 10.1126/sciadv.1700423. eCollection 2017 July.

  14. Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation. Lokareddy, R., Sankhala, R., Roy, A., Afonine, P., Motwani, T., Teschke, C.M., Parent, K.N., and Cingolani, G. (2017) Nature Communications, 8:14310. doi: 10.1038/ncomms14310.

  15. NMR assignments for the insertion domain of bacteriophage Sf6 coat protein. Tripler, T.N., Teschke, C.M.*, Alexandrescu, A.T.* (2017) Biomol. NMR Assignments, 11:35-38. doi: 10.1007/s12104-016-9716-5. Epub 2016 Oct 31. *co-corresponding authors

  16. Localization of the Houdinisome (Ejection Proteins) inside the Bacteriophage P22 Virion by Bubblegram Imaging. Wu W, Leavitt JC, Cheng N, Gilcrease EB, Motwani T, Teschke CM, Casjens SR, Steven AC. MBio. 2016 Aug 9;7(4). pii: e01152-16. doi: 10.1128/mBio.01152-16. PMID: 27507825

  17. Measurement of the accurate mass of a 50 MDa infectious virus. Keifer DZ, Motwani T, Teschke CM, Jarrold MF. Rapid Commun Mass Spectrom. 2016 Sep 15;30(17):1957-62. doi10.1002/rcm.7673. PMID:27501430

  18. Acquiring Structural Information on Virus Particles with Charge Detection Mass Spectrometry. Keifer DZ, Motwani T, Teschke CM, Jarrold MF. J Am Soc Mass Spectrom. 2016 Jun;27(6):1028-36. doi: 10.1007/s13361-016-1362-8. Epub 2016 Mar 28. PMID: 27020925

  19. Contextual Role of a Salt Bridge in the Phage P22 Coat Protein I-Domain. Harprecht C, Okifo O, Robbins KJ, Motwani T, Alexandrescu AT, Teschke CM. J Biol Chem. 2016 May 20;291(21):11359-72. doi: 10.1074/jbc.M116.716910. Epub 2016 Mar 22. PMID: 27006399

  20. Mechanism of Protein Denaturation: Partial Unfolding of the P22 Coat Protein I-Domain by Urea Binding. Newcomer RL, Fraser LC, Teschke CM, Alexandrescu AT. Biophys J. 2015 Dec 15;109(12):2666-77. doi: 10.1016/j.bpj.2015.11.010. PMID: 26682823

  21. A Molecular Staple: D-Loops in the I Domain of Bacteriophage P22 Coat Protein Make Important Intercapsomer Contacts Required for Procapsid Assembly. D'Lima NG, Teschke CM. J Virol. 2015 Oct;89(20):10569-79. doi: 10.1128/JVI.01629-15. Epub 2015 Aug 12. PMID: 26269173 Free PMC Article

  22. A method to investigate protein association with intact sealed mycobacterial membrane vesicles. D'Lima NG, Teschke CM. Anal Biochem. 2015 Sep 15;485:109-11. doi: 10.1016/j.ab.2015.06.023. Epub 2015 Jun 20. PMID: 26099936

  23. Nature's favorite building block: Deciphering folding and capsid assembly of proteins with the HK97-fold. Suhanovsky MM, Teschke CM. Virology. 2015 May;479-480:487-97. doi: 10.1016/j.virol.2015.02.055. Epub 2015 Apr 8. PMID: 25864106 Free PMC Article

  24. NMR assignments for the insertion domain of bacteriophage CUS-3 coat protein. Tripler TN, Maciejewski MW, Teschke CM, Alexandrescu AT. Biomol NMR Assign. 2015 Oct;9(2):333-6. doi: 10.1007/s12104-015-9604-4. Epub 2015 Feb 19. PMID: 25694158

  25. Multiple functional roles of the accessory I-domain of bacteriophage P22 coat protein revealed by NMR structure and CryoEM modeling. Rizzo AA, Suhanovsky MM, Baker ML, Fraser LC, Jones LM, Rempel DL, Gross ML, Chiu W, Alexandrescu AT, Teschke CM. Structure. 2014 Jun 10;22(6):830-41. doi: 10.1016/j.str.2014.04.003. Epub 2014 May 15. PMID: 24836025 Free PMC Article

  26. Highly specific salt bridges govern bacteriophage P22 icosahedral capsid assembly: identification of the site in coat protein responsible for interaction with scaffolding protein. Cortines JR, Motwani T, Vyas AA, Teschke CM. J Virol. 2014 May;88(10):5287-97. doi: 10.1128/JVI.00036-14. Epub 2014 Mar 5. PMID: 24600011 Free PMC Article

  27. ADP-dependent conformational changes distinguish Mycobacterium tuberculosis SecA2 from SecA1. D'Lima NG, Teschke CM. J Biol Chem. 2014 Jan 24;289(4):2307-17. doi: 10.1074/jbc.M113.533323. Epub 2013 Dec 2. PMID: 24297168 Free PMC Article

  28. An intramolecular chaperone inserted in bacteriophage P22 coat protein mediates its chaperonin-independent folding. Suhanovsky MM, Teschke CM. J Biol Chem. 2013 Nov 22;288(47):33772-83. doi: 10.1074/jbc.M113.515312. Epub 2013 Oct 13. PMID: 24126914 Free PMC Article

  29. NMR assignments for the telokin-like domain of bacteriophage P22 coat protein. Rizzo AA, Fraser LC, Sheftic SR, Suhanovsky MM, Teschke CM, Alexandrescu AT. Biomol NMR Assign. 2013 Oct;7(2):257-60. doi: 10.1007/s12104-012-9422-x. Epub 2012 Sep 18. PMID: 22987227 Free PMC Article

  30. Themes and variations of viral small terminase proteins. Teschke CM. Structure. 2012 Aug 8;20(8):1291-2. doi: 10.1016/j.str.2012.07.007. No abstract available. PMID: 22884105 Free PMC Article

  31. Unraveling the role of the C-terminal helix turn helix of the coat-binding domain of bacteriophage P22 scaffolding protein. Padilla-Meier GP, Gilcrease EB, Weigele PR, Cortines JR, Siegel M, Leavitt JC, Teschke CM, Casjens SR. J Biol Chem. 2012 Sep 28;287(40):33766-80. Epub 2012 Aug 9.PMID: 22879595 Free PMC Article

  32. Stepwise molecular display utilizing icosahedral and helical complexes of phage coat and decoration proteins in the development of robust nanoscale display vehicles. Parent KN, Deedas CT, Egelman EH, Casjens SR, Baker TS, Teschke CM. Biomaterials. 2012 Aug;33(22):5628-37. doi: 10.1016/j.biomaterials.2012.04.026. Epub 2012 May 8. PMID: 22575828 Free PMC Article

  33. The energetic contributions of scaffolding and coat proteins to the assembly of bacteriophage procapsids. Zlotnick A, Suhanovsky MM, Teschke CM. Virology. 2012 Jun 20;428(1):64-9. doi: 10.1016/j.virol.2012.03.017. Epub 2012 Apr 20. PMID: 22520942 Free PMC Article

  34. Decoding bacteriophage P22 assembly: identification of two charged residues in scaffolding protein responsible for coat protein interaction. Cortines JR, Weigele PR, Gilcrease EB, Casjens SR, Teschke CM. Virology. 2011 Dec 5;421(1):1-11. doi: 10.1016/j.virol.2011.09.005. Epub 2011 Oct 4. PMID: 21974803 Free PMC Article

  35. Bacteriophage P22 capsid size determination: roles for the coat protein telokin-like domain and the scaffolding protein amino-terminus. Suhanovsky MM, Teschke CM. Virology. 2011 Sep 1;417(2):418-29. doi: 10.1016/j.virol.2011.06.025. Epub 2011 Jul 23. PMID: 21784500